Quality of life in young‐ compared with late‐onset Parkinson's disease
Identifieur interne : 000177 ( Main/Exploration ); précédent : 000176; suivant : 000178Quality of life in young‐ compared with late‐onset Parkinson's disease
Auteurs : M. Duleeka W. Knipe [Royaume-Uni] ; Mirdhu M. Wickremaratchi [Royaume-Uni] ; Emma Wyatt-Haines [Royaume-Uni] ; Huw R. Morris [Royaume-Uni] ; Yoav Ben-Shlomo [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-09.
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- KwdEn :
Abstract
The impact of Parkinson's disease on quality of life may vary depending on age at onset. We investigated the effect of age at onset on quality of life in a large Parkinson's disease population (n = 426) using a disease‐specific rating scale (PDQ‐39) and with careful adjustment for confounding and intermediary factors. We also explored the relationship between depression and excessive daytime sleepiness by age at onset and compared this with the general population. We found that a younger age at onset was significantly associated with worse overall quality of life scores (odds ratio, 2.66; 95% confidence interval, 1.39–5.09; P = .003), but this was attenuated by adjustment for depression as an intermediary factor (odds ratio, 1.86; 95% confidence interval, 0.84–4.11; P = .13). Younger onset was also a risk factor for poor emotional well‐being independent of depression status. Risk of depression and excessive daytime sleepiness were elevated in patients with Parkinson's disease compared with controls (odds ratio, 2.99; 95% confidence interval, 1.93–4.65; P < .001; and odds ratio, 3.84; 95% confidence interval, 2.56–5.75; P < .001, respectively), with similar findings seen in both early‐ and late‐onset groups. Our study highlights the need for accurate diagnosis and treatment of depression in younger‐onset patients in order to improve quality of life. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23763
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09">2011-09</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2011">2011</biblScope><biblScope unit="page" to="2018">2018</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">30C13E93FE6B67E1686095DA98954309E727CC87</idno><idno type="DOI">10.1002/mds.23763</idno><idno type="ArticleID">MDS23763</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>age of onset</term><term>depression</term><term>excessive somnolence disorder</term><term>quality of life</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The impact of Parkinson's disease on quality of life may vary depending on age at onset. We investigated the effect of age at onset on quality of life in a large Parkinson's disease population (n = 426) using a disease‐specific rating scale (PDQ‐39) and with careful adjustment for confounding and intermediary factors. We also explored the relationship between depression and excessive daytime sleepiness by age at onset and compared this with the general population. We found that a younger age at onset was significantly associated with worse overall quality of life scores (odds ratio, 2.66; 95% confidence interval, 1.39–5.09; P = .003), but this was attenuated by adjustment for depression as an intermediary factor (odds ratio, 1.86; 95% confidence interval, 0.84–4.11; P = .13). Younger onset was also a risk factor for poor emotional well‐being independent of depression status. Risk of depression and excessive daytime sleepiness were elevated in patients with Parkinson's disease compared with controls (odds ratio, 2.99; 95% confidence interval, 1.93–4.65; P < .001; and odds ratio, 3.84; 95% confidence interval, 2.56–5.75; P < .001, respectively), with similar findings seen in both early‐ and late‐onset groups. Our study highlights the need for accurate diagnosis and treatment of depression in younger‐onset patients in order to improve quality of life. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Knipe, M Duleeka W" sort="Knipe, M Duleeka W" uniqKey="Knipe M" first="M. Duleeka W." last="Knipe">M. Duleeka W. Knipe</name></noRegion><name sortKey="Ben Hlomo, Yoav" sort="Ben Hlomo, Yoav" uniqKey="Ben Hlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><name sortKey="Morris, Huw R" sort="Morris, Huw R" uniqKey="Morris H" first="Huw R." last="Morris">Huw R. Morris</name><name sortKey="Morris, Huw R" sort="Morris, Huw R" uniqKey="Morris H" first="Huw R." last="Morris">Huw R. Morris</name><name sortKey="Wickremaratchi, Mirdhu M" sort="Wickremaratchi, Mirdhu M" uniqKey="Wickremaratchi M" first="Mirdhu M." last="Wickremaratchi">Mirdhu M. Wickremaratchi</name><name sortKey="Wyatt Aines, Emma" sort="Wyatt Aines, Emma" uniqKey="Wyatt Aines E" first="Emma" last="Wyatt-Haines">Emma Wyatt-Haines</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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